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KMID : 0613820040140020263
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Journal of Life Science
2004 Volume.14 No. 2 p.263 ~ p.0
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Effect of Fibroblast Growth Factor-2 on the Sprouting in Vascular Endothelial Cells
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Kim Hwan-Gyu
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Abstract
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The sprouting of vascular endothelial cells is an initial step in angiogenesis. Matrix metalloproteinases can associate with integrin on the surface of endothelial cells, thereby promoting angiogenesis. The purpose of this study was to test if fibroblast growth factor-2 (FGF-2) can regulate the sprouting in porcine pulmonary artery endothelial cells. FGF-2 induced sprouting and secretion of MMP-2 and plasmin. FGF-2 also induced the expression of integrin Mac-1, which is inhibited IS20I. Addition of BB-94, α2-antiplasmin and IS20I inhibited FGF-2-induced sprouting activity. Therefore, FGF-2-induced sprouting activity in PPAECs may be accomplished by secretion of proteinases such as MMP-2 and plasmin and integrin expression.
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KEYWORD
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FGF-2, MMPs, plasmin, integrin
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